PittsburghV1, France, Analysis, bibRecord, 000451

Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

Identifieur interne : 000451 ( France/Analysis ); précédent : 000450; suivant : 000452

Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

Auteurs : Joseph P. Broderick [États-Unis] ; Yuko Y. Palesch [États-Unis] ; Andrew M. Demchuk [Canada] ; Sharon D. Yeatts [États-Unis] ; Pooja Khatri [États-Unis] ; Michael D. Hill [Canada] ; Edward C. Jauch [États-Unis] ; Tudor G. Jovin [États-Unis] ; Bernard Yan [Australie] ; Frank L. Silver [Canada] ; Rudigervon Kummer [Allemagne] ; Carlos A. Molina [Espagne] ; Bart M. Demaerschalk [États-Unis] ; Ronald Budzik [États-Unis] ; Wayne M. Clark [États-Unis] ; Osama O. Zaidat [États-Unis] ; Tim W. Malisch [États-Unis] ; Mayank Goyal [Canada] ; Wouter J. Schonewille [Pays-Bas] ; Mikael Mazighi [France] ; Stefan T. Engelter [Suisse] ; Craig Anderson [Canada] ; Judith Spilker [États-Unis] ; Janice Carrozzella [États-Unis] ; Karla J. Ryckborst [Canada] ; L. Scott Janis [États-Unis] ; Renée H. Martin [États-Unis] ; Lydia D. Foster [États-Unis] ; Thomas A. Tomsick [États-Unis]

Source :

The New England journal of medicine [ 0028-4793 ] ; 2013.

RBID : Pascal:13-0119602

Descripteurs français

Pascal (Inist)
- Accident cérébrovasculaire, Voie endovasculaire, Traitement, Voie intraveineuse, t-Plasminogen activator, Etude comparative, Médecine.
Wicri :
- topic : Médecine.

English descriptors

KwdEn :
- Comparative study, Endovascular route, Intravenous administration, Medicine, Stroke, Treatment, t-Plasminogen activator.

Abstract

BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onset to receive additional endovascular therapy or intravenous t-PA alone, in a 2:1 ratio. The primary outcome measure was a modified Rankin scale score of 2 or less (indicating functional independence) at 90 days (scores range from 0 to 6, with higher scores indicating greater disability). RESULTS The study was stopped early because of futility after 656 participants had undergone randomization (434 patients to endovascular therapy and 222 to intravenous t-PA alone).

Affiliations:

Allemagne, Australie, Canada, Espagne, France, Pays-Bas, Suisse, États-Unis
Alberta, Catalogne, District de Dresde, Nouvelle-Galles du Sud, Ontario, Oregon, Pennsylvanie, Saxe (Land), Utrecht (province), Île-de-France
Barcelone, Calgary, Dresde, Paris, Pittsburgh, Portland, Sydney, Toronto, Utrecht
Université de Calgary, Université de Toronto

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002579
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to stream Main, to step Merge: 007437
to stream Main, to step Curation: 006F98
to stream Main, to step Exploration: 006F98
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Pascal:13-0119602

Le document en format XML

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<author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A." last="Tomsick">Thomas A. Tomsick</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke</title>
<author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P." last="Broderick">Joseph P. Broderick</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center</s1>
<s2>Cincinnati</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cincinnati</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y." last="Palesch">Yuko Y. Palesch</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charleston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M." last="Demchuk">Andrew M. Demchuk</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Seaman Family Magnetic Resonance Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary</s1>
<s2>Calgary, AB</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D." last="Yeatts">Sharon D. Yeatts</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charleston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center</s1>
<s2>Cincinnati</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cincinnati</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D." last="Hill">Michael D. Hill</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Seaman Family Magnetic Resonance Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary</s1>
<s2>Calgary, AB</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C." last="Jauch">Edward C. Jauch</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Emergency Medicine, Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charleston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G." last="Jovin">Tudor G. Jovin</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Stroke Institute, University of Pittsburgh Medical Center</s1>
<s2>Pittsburgh</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne</s1>
<s2>Melbourne, VIC</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, VIC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Silver, Frank L" sort="Silver, Frank L" uniqKey="Silver F" first="Frank L." last="Silver">Frank L. Silver</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>University of Toronto, Department of Medicine, Division of Neurology and the University Health Network</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto</wicri:noRegion>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kummer, Rudigervon" sort="Kummer, Rudigervon" uniqKey="Kummer R" first="Rudigervon" last="Kummer">Rudigervon Kummer</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neuroradiology, Dresden University Stroke Center, University Hospital</s1>
<s2>Dresden</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molina, Carlos A" sort="Molina, Carlos A" uniqKey="Molina C" first="Carlos A." last="Molina">Carlos A. Molina</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurovascular Unit, Department of Neurology, Hospital Universitari Vail d'Hebron</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Demaerschalk, Bart M" sort="Demaerschalk, Bart M" uniqKey="Demaerschalk B" first="Bart M." last="Demaerschalk">Bart M. Demaerschalk</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Neurology, Mayo Clinic</s1>
<s2>Phoenix, AZ</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Phoenix, AZ</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Budzik, Ronald" sort="Budzik, Ronald" uniqKey="Budzik R" first="Ronald" last="Budzik">Ronald Budzik</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>OhioHealth Neuroscience Institute, Riverside Methodist Hospital</s1>
<s2>Columbus, OH</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Columbus, OH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clark, Wayne M" sort="Clark, Wayne M" uniqKey="Clark W" first="Wayne M." last="Clark">Wayne M. Clark</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Oregon Stroke Center, Oregon Health and Science University</s1>
<s2>Portland</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Portland</settlement>
<region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zaidat, Osama O" sort="Zaidat, Osama O" uniqKey="Zaidat O" first="Osama O." last="Zaidat">Osama O. Zaidat</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Radiology, Medical College of Wisconsin</s1>
<s2>Milwaukee</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Milwaukee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malisch, Tim W" sort="Malisch, Tim W" uniqKey="Malisch T" first="Tim W." last="Malisch">Tim W. Malisch</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Alexian Brothers Medical Center</s1>
<s2>Elk Grove Village, IL</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Alexian Brothers Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Seaman Family Magnetic Resonance Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary</s1>
<s2>Calgary, AB</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J." last="Schonewille">Wouter J. Schonewille</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>St. Antonius Hospital</s1>
<s2>Nieuwegein</s2>
<s3>NLD</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>St. Antonius Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Neurology and Stroke Center, Bichat University Hospital</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Neurology, Basel University Hospital</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney</s1>
<s2>Sydney</s2>
<s3>CAN</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Spilker, Judith" sort="Spilker, Judith" uniqKey="Spilker J" first="Judith" last="Spilker">Judith Spilker</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center</s1>
<s2>Cincinnati</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cincinnati</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carrozzella, Janice" sort="Carrozzella, Janice" uniqKey="Carrozzella J" first="Janice" last="Carrozzella">Janice Carrozzella</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center</s1>
<s2>Cincinnati</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cincinnati</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ryckborst, Karla J" sort="Ryckborst, Karla J" uniqKey="Ryckborst K" first="Karla J." last="Ryckborst">Karla J. Ryckborst</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Seaman Family Magnetic Resonance Research Centre, Departments of Clinical Neurosciences and Radiology, Hotchkiss Brain Institute, University of Calgary</s1>
<s2>Calgary, AB</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
<author><name sortKey="Janis, L Scott" sort="Janis, L Scott" uniqKey="Janis L" first="L. Scott" last="Janis">L. Scott Janis</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>National Institute of Neurological Disorders and Stroke, National Institutes of Health</s1>
<s2>Bethesda, MD</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Bethesda, MD</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Renee H" sort="Martin, Renee H" uniqKey="Martin R" first="Renée H." last="Martin">Renée H. Martin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charleston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D." last="Foster">Lydia D. Foster</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Public Health Sciences, Medical University of South Carolina</s1>
<s2>Charleston</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Charleston</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A." last="Tomsick">Thomas A. Tomsick</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Neuroscience Institute, University of Cincinnati Academic Health Center</s1>
<s2>Cincinnati</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cincinnati</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term>
<term>Endovascular route</term>
<term>Intravenous administration</term>
<term>Medicine</term>
<term>Stroke</term>
<term>Treatment</term>
<term>t-Plasminogen activator</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Accident cérébrovasculaire</term>
<term>Voie endovasculaire</term>
<term>Traitement</term>
<term>Voie intraveineuse</term>
<term>t-Plasminogen activator</term>
<term>Etude comparative</term>
<term>Médecine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain. METHODS We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onset to receive additional endovascular therapy or intravenous t-PA alone, in a 2:1 ratio. The primary outcome measure was a modified Rankin scale score of 2 or less (indicating functional independence) at 90 days (scores range from 0 to 6, with higher scores indicating greater disability). RESULTS The study was stopped early because of futility after 656 participants had undergone randomization (434 patients to endovascular therapy and 222 to intravenous t-PA alone).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Alberta</li>
<li>Catalogne</li>
<li>District de Dresde</li>
<li>Nouvelle-Galles du Sud</li>
<li>Ontario</li>
<li>Oregon</li>
<li>Pennsylvanie</li>
<li>Saxe (Land)</li>
<li>Utrecht (province)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Calgary</li>
<li>Dresde</li>
<li>Paris</li>
<li>Pittsburgh</li>
<li>Portland</li>
<li>Sydney</li>
<li>Toronto</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université de Calgary</li>
<li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P." last="Broderick">Joseph P. Broderick</name>
</noRegion>
<name sortKey="Budzik, Ronald" sort="Budzik, Ronald" uniqKey="Budzik R" first="Ronald" last="Budzik">Ronald Budzik</name>
<name sortKey="Carrozzella, Janice" sort="Carrozzella, Janice" uniqKey="Carrozzella J" first="Janice" last="Carrozzella">Janice Carrozzella</name>
<name sortKey="Clark, Wayne M" sort="Clark, Wayne M" uniqKey="Clark W" first="Wayne M." last="Clark">Wayne M. Clark</name>
<name sortKey="Demaerschalk, Bart M" sort="Demaerschalk, Bart M" uniqKey="Demaerschalk B" first="Bart M." last="Demaerschalk">Bart M. Demaerschalk</name>
<name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D." last="Foster">Lydia D. Foster</name>
<name sortKey="Janis, L Scott" sort="Janis, L Scott" uniqKey="Janis L" first="L. Scott" last="Janis">L. Scott Janis</name>
<name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C." last="Jauch">Edward C. Jauch</name>
<name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G." last="Jovin">Tudor G. Jovin</name>
<name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name>
<name sortKey="Malisch, Tim W" sort="Malisch, Tim W" uniqKey="Malisch T" first="Tim W." last="Malisch">Tim W. Malisch</name>
<name sortKey="Martin, Renee H" sort="Martin, Renee H" uniqKey="Martin R" first="Renée H." last="Martin">Renée H. Martin</name>
<name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y." last="Palesch">Yuko Y. Palesch</name>
<name sortKey="Spilker, Judith" sort="Spilker, Judith" uniqKey="Spilker J" first="Judith" last="Spilker">Judith Spilker</name>
<name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A." last="Tomsick">Thomas A. Tomsick</name>
<name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D." last="Yeatts">Sharon D. Yeatts</name>
<name sortKey="Zaidat, Osama O" sort="Zaidat, Osama O" uniqKey="Zaidat O" first="Osama O." last="Zaidat">Osama O. Zaidat</name>
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<country name="Canada"><region name="Alberta"><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M." last="Demchuk">Andrew M. Demchuk</name>
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<name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name>
<name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name>
<name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D." last="Hill">Michael D. Hill</name>
<name sortKey="Ryckborst, Karla J" sort="Ryckborst, Karla J" uniqKey="Ryckborst K" first="Karla J." last="Ryckborst">Karla J. Ryckborst</name>
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<country name="Australie"><noRegion><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name>
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<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Kummer, Rudigervon" sort="Kummer, Rudigervon" uniqKey="Kummer R" first="Rudigervon" last="Kummer">Rudigervon Kummer</name>
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<country name="Espagne"><region name="Catalogne"><name sortKey="Molina, Carlos A" sort="Molina, Carlos A" uniqKey="Molina C" first="Carlos A." last="Molina">Carlos A. Molina</name>
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<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J." last="Schonewille">Wouter J. Schonewille</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name>
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<country name="Suisse"><noRegion><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name>
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</affiliations>
</record>

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   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:13-0119602
   |texte=   Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke
}}

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Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke

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